Medical-physiological simulators: the necessity and problems

R.D. Grygoryan, I.I. Deriev, T.V. Aksenova, A.N. Lisov

Abstract


This paper analyzes basic conceptual and technological problems encountered in creation of special software simulators (SSS) known under terms of «virtual physiological human» and «virtual patient». SSS can have two applications: 1) educational – for better studying of human physiology; 2) clinical – for improving the accuracy of diagnosis and for optimizing of a treatment of non-trivial diseases. It is argued that the SSS should be based on quantitative mathematical models of physiological systems and processes. SSS must provide both execution of computer imitational experiments (CIE) and their results’ analysis. Each CIE should be in accordance with the scenario generated by the user interface (UI). It is desirable that the SSS based on two modules: hard and flexible. The hard module implements the model with the boundary conditions of their adequacy. The flexible module governs both models’ constants available for modification through UI and parameters specifying scenarios of CIE. It is assumed that most promising class of SSS should combine computer animations with standard and optional programs visualizing CIE’s results. Problems arising in development of SSS for modeling of physiological responses of human energy mega system to factors that create an energy deficit in a group of cells are analyzed. Main problems accompanying a versioning of SSS capable to simulate scenarios for the correction of specific pathologies are also discussed.

Prombles in programming 2014; 2-3: 197-204


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