Modeling of pancreas-liver interaction under controlled hemodynamics

Abstract

Autonomous software (AS) was created to simulate the dynamics of the glucose-insulin-glycogen-glucagon relationship in a healthy person. Our AS is based on a quantitative mathematical model consisting of three components: a model describing the pancreas-liver and the pancreas-skeletal muscles relationships; a model describing blood circulation in the branched cardiovascular system, taking into account neurohumoral regu lators of cardiac function, vascular tone and total blood volume; and a model describing blood filtration in the renal glomeruli and tubular reabsorption. A glucose tolerance test (GTT) was also programmed. Test simulations demonstrated adequate model responses. The program is integrated into a specialized computer simulator (SCS). It allows studying mechanisms that, depending on the dynamics of exogenous and endoge nous physicochemical variables, dynamically form multidimensional health landscape of biometric indica tors. The effect of extreme blood flow increase on the dynamics of the main variables of the model was also simulated without additional carbohydrate intake. AS is created in C#, and can be delivered as an Exe module for IBM-compatible computers. Medical students can be additional users of the AP as an additional didactic tool. The AS ensures the preservation of all simulation data for future reviews and publications. The AS can be used by future endocrinologists in their training. Physiologists interested in the integrative physi ology of cellular life support are recommended to use the SCS.

Problems in programming 2026; 2: 49-57